Liver Inclusion Appears to Be Protective Against Graft Loss-Due-to Chronic But Not Acute Rejection Following Intestinal Transplantation

In intestinal transplantation, while other centers have shown that liver-including allografts significantly more favorable graft survival and loss-due-to chronic rejection (CHR) rates, our center has consistently modified multivisceral (MMV) full (MV) acute cellular (ACR) severe ACR rates compared with isolated intestine (I) liver-intestine (LI) allografts. the attempt to resolve this apparent discrepancy, we performed stepwise Cox multivariable analyses of hazard developing (AR) vs. CHR among 350 consecutive transplants at long-term follow-up (median: 13.5 years post-transplant). Observed percentages AR were 14.3% (50/350) 6.6% (23/350), respectively. Only one baseline variable was selected into model indicating a lower rate AR: Transplant Type MMV or MV ( p < 0.000001). Conversely, two variables CHR: Received Donor Liver (LI MV) = 0.002) Induction 0.007). summary, MMV/MV (who receive extensive native lymphoid tissue removal) offered protection against AR, liver-containing grafts appeared offer CHR, supporting results studies.